Project Funding Details

Title
A pathway approach to study the biological effects of vitamin D on colorectal carcinogenesis: Exploration of gene-nutrient, gene-environment and gene-gene interactions
Alt. Award Code
IIG_2011_443
Funding Organization
World Cancer Research Fund Netherlands
Budget Dates
2012-01-01 to 2016-06-30
Principal Investigator
Jenab, Mazda
Institution
International Agency For Research On Cancer
Region
Europe & Central Asia
Location
Lyon, FR

Collaborators

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Technical Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide. Despite advances in screening/treatment, its incidence is increasing with modest mortality decline. Thus, the identification of effective CRC preventive factors can have important public health implications. Recently, higher vitamin D exposure has been shown to be CRC protective by several studies, the largest of which is based on the EPIC cohort. The current proposal builds on this study and intends to explore the influence of multiple contributing pathways including interactions with genes related to vitamin D metabolism/action and genetic predisposition to CRC risk. A clearer understanding of how vitamin D may be effective will allow its integration into an overall comprehensive preventive framework aimed at CRC control. The overall goal is to enhance scientific understanding of its CRC protective effects and to contribute to evidence needed for development of effective CRC preventive public health policies.

Public Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide. Despite advances in screening/treatment, its incidence is increasing with modest mortality decline. Thus, the identification of effective CRC preventive factors can have important public health implications. Recently, higher vitamin D exposure has been shown to be CRC protective by several studies, the largest of which is based on the EPIC cohort. The current proposal builds on this study and intends to explore the influence of multiple contributing pathways including interactions with genes related to vitamin D metabolism/action and genetic predisposition to CRC risk. A clearer understanding of how vitamin D may be effective will allow its integration into an overall comprehensive preventive framework aimed at CRC control. The overall goal is to enhance scientific understanding of its CRC protective effects and to contribute to evidence needed for development of effective CRC preventive public health policies.

Cancer Types

  • Colon and Rectal Cancer

Common Scientific Outline (CSO) Research Areas

  • 2.3 Causes of Cancer/Etiology Genes/ Genetic Polymorphisms Interacting with Exo-/Endo-genous Factors